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Premature aging and rheumatoid arthritis

Researchers have observed that in the body aging, like many other diseases, rheumatoid arthritis causes multiple systems more quickly than expected. Accelerated premature aging is the process in which appeared the phenomenon that cells affected by diseases damage at the molecular level resulting in poorer function. It can be considered that the concept of accelerated aging is the appropriate explanation for the increased mortality in people with RA.

rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory disease mainly manifested as synovial inflammation leads to cartilage damage and destruction of the infrastructure as a whole. Although the final common symptoms are dominant, the disease is preceded by abnormal immune letter that is not specific, but it was clear the system and for many years before the onset of disease

The RA-old relationship is different from the autoimmune disease specific organs, such as diabetes or systemic lupus erythematosus culminating earlier in life. However, rheumatoid arthritis does not stand alone in this respect. Many other chronic inflammatory diseases mainly resulted from aging. This important role of age in the development of autoimmune diseases selected questions whether immune aging is a factor contributing to disability and tolerance is part of a process of degeneration Immune System. Indeed, these autoantibodies are often found in healthy older people. Generally, the rheumatoid factor related to low titered age, but otherwise no different from autoantibodies in autoimmune diseases.

rheumatoid arthritis

The concept that autoimmune disease is a consequence of the aging immune response is contrary to intuition. Overall, the immune system is aged less responsive to antigen challenge; it is more difficult in the elderly to elicit an immune response to an antigen in adults than children. As a result, aging leads to the decrease in the vaccine response. Not only is the innate affected by immune aging but also the adaptive immune systems. The innate immune system in the elderly is constitutively active and levels of inflammatory cytokines. The immunological evidence of immune aging is illustrated by the growing rate and incidence of infections, failure to mount responses vaccine and reactivation of chronic infection with age. Epidemiological data shows clinical evidence of immune aging were present, though subtle, middle-aged adult, not just a feature of the very old.

The epidemiological data clearly shows that age is an important risk factor for the development of RA.